Open channel block by gadolinium ion of the stretch-inactivated ion channel in mdx myotubes

Ion channel activity drives ion channel expression.

How does voltage open an ion channel?

Neurons transmit information through electrical signals generated by voltage-gated ion channels. These channels consist of a large superfamily of proteins that form channels selective for potassium, sodium, or calcium ions. In this review we focus on the molecular mechanisms by which these channels convert changes in membrane voltage into the opening and closing of "gates" that turn ion conduct...

Ion-Channel Gating: Twist to open

Three-dimensional images of the open state of the nicotinic acetylcholine receptor have been obtained at 9 A resolution. Comparison with the closed state reveals the structural basis of channel gating.

Long alkylchain iminosugars block the HCV p7 ion channel.

Ion permeation through neuronal nAChR ion channel

Alzheimer’s dementia is related to loss of inter-neuron communication by nicotinic acetylcholine receptors (nAChR) at post synaptic neurons, and successful therapy approaches rely e.g. on modulations of response signals initiated by ion flux through the receptor integrated ion channel. We have evaluated Umbrella Sampling (US) and Steered Molecular Dynamics (SMD) pulling for calculation of the p...